Drug interactions
Bosentan + Lomitapide
Severity: Moderate
Bosentan and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is metabolised by CYP3A4, so bosentan may reduce its exposure and weaken LDL-lowering effect. Both drugs can also cause liver enzyme elevations, adding to hepatic monitoring concerns.
What this interaction means in plain words
Bosentan and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Lomitapide belongs to Cardiovascular.
Why it happens
Bosentan induces CYP3A4, increasing lomitapide clearance.
What to do
Monitor LDL cholesterol response and liver enzymes, adjusting lomitapide dose as appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Bosentan with Lomitapide?
MediHelp rates the interaction as moderate. Bosentan and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is metabolised by CYP3A4, so bosentan may reduce its exposure and weaken LDL-lowering effect. Both drugs can also cause liver enzyme elevations, adding to hepatic monitoring concerns.
How serious is the interaction between Bosentan and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LDL cholesterol response and liver enzymes, adjusting lomitapide dose as appropriate.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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