Drug interactions
Bosentan + Macimorelin
Severity: Moderate
Bosentan and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce macimorelin exposure, which can cause a false-positive result on the growth hormone deficiency stimulation test. This leads to misdiagnosis rather than direct toxicity.
What this interaction means in plain words
Bosentan and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Macimorelin belongs to Endocrine.
Why it happens
Bosentan induces CYP3A4, lowering macimorelin levels and blunting the stimulated growth hormone response.
What to do
Interpret the test with caution and, when feasible, stop the inducer with an adequate washout before testing. Consider an alternative diagnostic test if bosentan cannot be interrupted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Bosentan with Macimorelin?
MediHelp rates the interaction as moderate. Bosentan and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may reduce macimorelin exposure, which can cause a false-positive result on the growth hormone deficiency stimulation test. This leads to misdiagnosis rather than direct toxicity.
How serious is the interaction between Bosentan and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Interpret the test with caution and, when feasible, stop the inducer with an adequate washout before testing. Consider an alternative diagnostic test if bosentan cannot be interrupted.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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