Drug interactions
Bosentan + Nisoldipine
Severity: Moderate
Bosentan and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nisoldipine is highly dependent on CYP3A4 and has low bioavailability, so bosentan may reduce its concentrations. Antihypertensive effect could be weakened.
What this interaction means in plain words
Bosentan and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Nisoldipine belongs to Cardiovascular.
Why it happens
Bosentan induces intestinal and hepatic CYP3A4, increasing nisoldipine first-pass metabolism.
What to do
Monitor blood pressure and adjust nisoldipine dose or choose another calcium channel blocker if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Bosentan with Nisoldipine?
MediHelp rates the interaction as moderate. Bosentan and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nisoldipine is highly dependent on CYP3A4 and has low bioavailability, so bosentan may reduce its concentrations. Antihypertensive effect could be weakened.
How serious is the interaction between Bosentan and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust nisoldipine dose or choose another calcium channel blocker if control is lost.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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