Drug interactions
Bosentan + Osilodrostat
Severity: Moderate
Bosentan and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and may lower osilodrostat exposure, potentially weakening control of cortisol. Loss of effect could lead to recurrent hypercortisolism.
What this interaction means in plain words
Bosentan and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Osilodrostat belongs to Endocrine.
Why it happens
Induction of CYP3A4 by bosentan increases osilodrostat clearance.
What to do
Monitor serum or urinary cortisol and clinical signs of hypercortisolism when starting or stopping bosentan. Increase the osilodrostat dose if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Bosentan with Osilodrostat?
MediHelp rates the interaction as moderate. Bosentan and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is a moderate CYP3A4 inducer and may lower osilodrostat exposure, potentially weakening control of cortisol. Loss of effect could lead to recurrent hypercortisolism.
How serious is the interaction between Bosentan and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum or urinary cortisol and clinical signs of hypercortisolism when starting or stopping bosentan. Increase the osilodrostat dose if control is lost.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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