Drug interactions
Bosentan + Osimertinib
Severity: Moderate
Bosentan and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib is metabolized by CYP3A4, and inducers can lower its exposure. Bosentan, a moderate inducer, may reduce its efficacy in lung cancer.
What this interaction means in plain words
Bosentan and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Osimertinib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, increasing osimertinib metabolism.
What to do
Avoid if feasible by selecting an alternative to bosentan. If used together, monitor for disease progression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Bosentan with Osimertinib?
MediHelp rates the interaction as moderate. Bosentan and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib is metabolized by CYP3A4, and inducers can lower its exposure. Bosentan, a moderate inducer, may reduce its efficacy in lung cancer.
How serious is the interaction between Bosentan and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if feasible by selecting an alternative to bosentan. If used together, monitor for disease progression.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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