Drug interactions
Bosentan + Paricalcitol
Severity: Minor
Bosentan and Paricalcitol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may modestly lower paricalcitol exposure through CYP3A4 induction. The effect on parathyroid hormone suppression is likely small but could reduce efficacy.
What this interaction means in plain words
Bosentan and Paricalcitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Paricalcitol belongs to Musculoskeletal.
Why it happens
Bosentan induces CYP3A4, increasing the metabolism of paricalcitol.
What to do
Monitor intact PTH and serum calcium and phosphate after starting or stopping bosentan. Adjust the paricalcitol dose according to these results.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Paricalcitol
- Carbamazepine + Paricalcitol Moderate
- Cholestyramine + Paricalcitol Moderate
- Clarithromycin + Paricalcitol Moderate
- Digoxin + Paricalcitol Moderate
- Ketoconazole + Paricalcitol Moderate
- Paricalcitol + Posaconazole Moderate
Frequently asked questions
Can I take Bosentan with Paricalcitol?
MediHelp rates the interaction as minor. Bosentan and Paricalcitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan may modestly lower paricalcitol exposure through CYP3A4 induction. The effect on parathyroid hormone suppression is likely small but could reduce efficacy.
How serious is the interaction between Bosentan and Paricalcitol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor intact PTH and serum calcium and phosphate after starting or stopping bosentan. Adjust the paricalcitol dose according to these results.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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