Drug interactions
Bosentan + Pomalidomide
Severity: Minor
Bosentan and Pomalidomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is partly metabolized by CYP3A4, but also by CYP1A2 and other routes. A CYP3A4 inducer is unlikely to change its exposure much, though both drugs are teratogenic and require strict pregnancy-prevention programs.
What this interaction means in plain words
Bosentan and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Pomalidomide belongs to Miscellaneous.
Why it happens
Bosentan may modestly increase CYP3A4-mediated pomalidomide metabolism, which is a minor clearance pathway.
What to do
No dose change is generally needed. Ensure both pregnancy-prevention programs are followed and monitor response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Bosentan with Pomalidomide?
MediHelp rates the interaction as minor. Bosentan and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pomalidomide is partly metabolized by CYP3A4, but also by CYP1A2 and other routes. A CYP3A4 inducer is unlikely to change its exposure much, though both drugs are teratogenic and require strict pregnancy-prevention programs.
How serious is the interaction between Bosentan and Pomalidomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Ensure both pregnancy-prevention programs are followed and monitor response.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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