Drug interactions
Bosentan + Rimegepant
Severity: Moderate
Bosentan and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and can lower rimegepant exposure. This may reduce its effectiveness for migraine.
What this interaction means in plain words
Bosentan and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Rimegepant belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by bosentan increases the metabolism of rimegepant.
What to do
Labeling advises avoiding rimegepant with moderate CYP3A4 inducers; if used together, watch for loss of migraine control and consider an alternative acute therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Rimegepant?
MediHelp rates the interaction as moderate. Bosentan and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is a moderate CYP3A4 inducer and can lower rimegepant exposure. This may reduce its effectiveness for migraine.
How serious is the interaction between Bosentan and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Labeling advises avoiding rimegepant with moderate CYP3A4 inducers; if used together, watch for loss of migraine control and consider an alternative acute therapy.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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