Drug interactions
Bosentan + Solifenacin
Severity: Moderate
Bosentan and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and may lower solifenacin exposure, potentially reducing efficacy for overactive bladder. The magnitude has not been well characterized.
What this interaction means in plain words
Bosentan and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Solifenacin belongs to Genitourinary.
Why it happens
Induction of CYP3A4 by bosentan increases solifenacin metabolism.
What to do
Monitor urinary symptom control and consider adjusting the solifenacin dose within labeled limits if efficacy is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Solifenacin?
MediHelp rates the interaction as moderate. Bosentan and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is a moderate CYP3A4 inducer and may lower solifenacin exposure, potentially reducing efficacy for overactive bladder. The magnitude has not been well characterized.
How serious is the interaction between Bosentan and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptom control and consider adjusting the solifenacin dose within labeled limits if efficacy is reduced.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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