Drug interactions
Bosentan + Vonoprazan
Severity: Moderate
Bosentan and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce vonoprazan exposure, potentially weakening acid suppression and healing or H. pylori eradication.
What this interaction means in plain words
Bosentan and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Bosentan induces CYP3A4, increasing vonoprazan metabolism.
What to do
Avoid strong inducers; with bosentan, monitor for reduced symptom control. Consider an alternative acid suppressant if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Bosentan with Vonoprazan?
MediHelp rates the interaction as moderate. Bosentan and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may reduce vonoprazan exposure, potentially weakening acid suppression and healing or H. pylori eradication.
How serious is the interaction between Bosentan and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong inducers; with bosentan, monitor for reduced symptom control. Consider an alternative acid suppressant if response is inadequate.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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