Drug interactions
Bosutinib + Calcium carbonate
Severity: Moderate
Bosutinib and Calcium carbonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib dissolves best in an acidic environment, and calcium carbonate raises gastric pH. Exposure to bosutinib may fall, which could reduce its antileukemic effect.
What this interaction means in plain words
Bosutinib and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Calcium carbonate belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces the pH-dependent solubility and absorption of bosutinib.
What to do
Take short-acting antacids such as calcium carbonate at least 2 hours apart from bosutinib. Prefer this approach over proton pump inhibitors where acid suppression is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Calcium carbonate?
MediHelp rates the interaction as moderate. Bosutinib and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib dissolves best in an acidic environment, and calcium carbonate raises gastric pH. Exposure to bosutinib may fall, which could reduce its antileukemic effect.
How serious is the interaction between Bosutinib and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take short-acting antacids such as calcium carbonate at least 2 hours apart from bosutinib. Prefer this approach over proton pump inhibitors where acid suppression is needed.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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