Drug interactions
Bosutinib + Crizotinib
Severity: Moderate
Bosutinib and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and may increase bosutinib concentrations. This raises the risk of bosutinib adverse effects such as diarrhea, hepatotoxicity and myelosuppression.
What this interaction means in plain words
Bosutinib and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Crizotinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4-mediated bosutinib metabolism.
What to do
Use a non-inhibiting alternative where possible. If combined, monitor liver enzymes, blood counts and GI tolerability, and consider reducing the bosutinib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Crizotinib?
MediHelp rates the interaction as moderate. Bosutinib and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and may increase bosutinib concentrations. This raises the risk of bosutinib adverse effects such as diarrhea, hepatotoxicity and myelosuppression.
How serious is the interaction between Bosutinib and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inhibiting alternative where possible. If combined, monitor liver enzymes, blood counts and GI tolerability, and consider reducing the bosutinib dose.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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