Drug interactions
Bosutinib + Dronedarone
Severity: Major
Bosutinib and Dronedarone: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP3A4 and P-glycoprotein, both of which handle bosutinib. Exposure to bosutinib may rise, increasing gastrointestinal, hepatic and myelosuppressive toxicity.
What this interaction means in plain words
Bosutinib and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosutinib belongs to Oncology; Dronedarone belongs to Cardiovascular.
Why it happens
Dual inhibition of CYP3A4 metabolism and P-glycoprotein efflux of bosutinib.
What to do
Avoid concurrent use if possible and consider an alternative antiarrhythmic. If used together, monitor liver tests, blood counts and GI tolerability and consider reducing the bosutinib dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Dronedarone?
MediHelp rates the interaction as major. Bosutinib and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone inhibits CYP3A4 and P-glycoprotein, both of which handle bosutinib. Exposure to bosutinib may rise, increasing gastrointestinal, hepatic and myelosuppressive toxicity.
How serious is the interaction between Bosutinib and Dronedarone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible and consider an alternative antiarrhythmic. If used together, monitor liver tests, blood counts and GI tolerability and consider reducing the bosutinib dose.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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