Drug interactions
Bosutinib + Haloperidol
Severity: Moderate
Bosutinib and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol may modestly inhibit CYP3A4 and raise bosutinib levels, increasing gastrointestinal, hepatic and other toxicities. Both agents can also prolong the QT interval.
What this interaction means in plain words
Bosutinib and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Haloperidol belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by haloperidol reducing bosutinib clearance, plus additive QT effects.
What to do
Monitor for bosutinib toxicity and liver function, and check the ECG if QT risk factors exist. Consider an alternative antipsychotic if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Haloperidol?
MediHelp rates the interaction as moderate. Bosutinib and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol may modestly inhibit CYP3A4 and raise bosutinib levels, increasing gastrointestinal, hepatic and other toxicities. Both agents can also prolong the QT interval.
How serious is the interaction between Bosutinib and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bosutinib toxicity and liver function, and check the ECG if QT risk factors exist. Consider an alternative antipsychotic if toxicity occurs.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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