Drug interactions
Bosutinib + Mefloquine
Severity: Moderate
Bosutinib and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine inhibits P-glycoprotein and may raise bosutinib concentrations, increasing gastrointestinal, hepatic and myelosuppressive toxicity. Bosutinib is also associated with QT prolongation, which may add to mefloquine's effect.
What this interaction means in plain words
Bosutinib and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Mefloquine belongs to Anti Parasitic.
Why it happens
P-glycoprotein inhibition by mefloquine increasing bosutinib exposure, with possible additive QT effects.
What to do
Monitor liver tests, blood counts, diarrhea and ECG. Consider reducing the bosutinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Mefloquine?
MediHelp rates the interaction as moderate. Bosutinib and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine inhibits P-glycoprotein and may raise bosutinib concentrations, increasing gastrointestinal, hepatic and myelosuppressive toxicity. Bosutinib is also associated with QT prolongation, which may add to mefloquine's effect.
How serious is the interaction between Bosutinib and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver tests, blood counts, diarrhea and ECG. Consider reducing the bosutinib dose if toxicity develops.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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