Drug interactions
Bosutinib + Omeprazole
Severity: Moderate
Bosutinib and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib solubility falls as pH rises, so omeprazole can reduce its absorption and lower exposure. This may reduce anticancer efficacy.
What this interaction means in plain words
Bosutinib and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Acid suppression raises gastric pH and reduces dissolution and absorption of bosutinib.
What to do
Avoid PPIs where possible; use a short-acting antacid or H2 blocker separated from bosutinib dosing. Monitor molecular response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Omeprazole?
MediHelp rates the interaction as moderate. Bosutinib and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib solubility falls as pH rises, so omeprazole can reduce its absorption and lower exposure. This may reduce anticancer efficacy.
How serious is the interaction between Bosutinib and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs where possible; use a short-acting antacid or H2 blocker separated from bosutinib dosing. Monitor molecular response.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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