Drug interactions
Bosutinib + Paliperidone
Severity: Moderate
Bosutinib and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib can inhibit P-glycoprotein, which may raise paliperidone concentrations. Both drugs can also prolong the QT interval, so the combination may add to arrhythmia risk.
What this interaction means in plain words
Bosutinib and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Paliperidone belongs to Central Nervous System.
Why it happens
P-gp inhibition by bosutinib reduces paliperidone efflux, plus additive QT prolongation.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes. Watch for paliperidone adverse effects and reduce its dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Paliperidone?
MediHelp rates the interaction as moderate. Bosutinib and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib can inhibit P-glycoprotein, which may raise paliperidone concentrations. Both drugs can also prolong the QT interval, so the combination may add to arrhythmia risk.
How serious is the interaction between Bosutinib and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes. Watch for paliperidone adverse effects and reduce its dose if needed.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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