Drug interactions
Bosutinib + Simvastatin
Severity: Minor
Bosutinib and Simvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib is a P-gp substrate, and simvastatin has only weak P-gp inhibitory effects. A clinically meaningful increase in bosutinib levels is unlikely.
What this interaction means in plain words
Bosutinib and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosutinib belongs to Oncology; Simvastatin belongs to Cardiovascular.
Why it happens
Possible weak P-gp inhibition by simvastatin reducing bosutinib efflux.
What to do
No dose adjustment is required. Monitor for bosutinib gastrointestinal and hepatic adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bosutinib and Simvastatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
- Darunavir + Simvastatin Contraindicated
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Simvastatin?
MediHelp rates the interaction as minor. Bosutinib and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosutinib is a P-gp substrate, and simvastatin has only weak P-gp inhibitory effects. A clinically meaningful increase in bosutinib levels is unlikely.
How serious is the interaction between Bosutinib and Simvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor for bosutinib gastrointestinal and hepatic adverse effects as usual.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
