Drug interactions
Bosutinib + Voriconazole
Severity: Major
Bosutinib and Voriconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inhibitors such as voriconazole substantially increase bosutinib plasma concentrations. This can lead to greater gastrointestinal toxicity, hepatotoxicity, myelosuppression and fluid retention.
What this interaction means in plain words
Bosutinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosutinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of bosutinib.
What to do
Avoid the combination and select an alternative antifungal with minimal CYP3A4 inhibition. If it is unavoidable, reduce the bosutinib dose per labeling and monitor liver tests and blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Voriconazole?
MediHelp rates the interaction as major. Bosutinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inhibitors such as voriconazole substantially increase bosutinib plasma concentrations. This can lead to greater gastrointestinal toxicity, hepatotoxicity, myelosuppression and fluid retention.
How serious is the interaction between Bosutinib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select an alternative antifungal with minimal CYP3A4 inhibition. If it is unavoidable, reduce the bosutinib dose per labeling and monitor liver tests and blood counts.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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