Drug interactions
Brentuximab + Carbamazepine
Severity: Minor
Brentuximab and Carbamazepine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a strong CYP3A4 inducer and may lower exposure to MMAE, the cytotoxic component released from brentuximab vedotin. Reduced MMAE exposure might diminish efficacy, though the effect is modest in labeling data.
What this interaction means in plain words
Brentuximab and Carbamazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brentuximab belongs to Oncology; Carbamazepine belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases metabolism of MMAE.
What to do
No dose adjustment is required; monitor response to brentuximab. Consider a non-inducing anticonvulsant where practical.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Brentuximab with Carbamazepine?
MediHelp rates the interaction as minor. Brentuximab and Carbamazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbamazepine is a strong CYP3A4 inducer and may lower exposure to MMAE, the cytotoxic component released from brentuximab vedotin. Reduced MMAE exposure might diminish efficacy, though the effect is modest in labeling data.
How serious is the interaction between Brentuximab and Carbamazepine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor response to brentuximab. Consider a non-inducing anticonvulsant where practical.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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