Drug interactions
Brentuximab + Itraconazole
Severity: Moderate
Brentuximab and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 and P-gp inhibitor and may raise MMAE exposure from brentuximab vedotin, increasing the risk of neutropenia and other toxicities.
What this interaction means in plain words
Brentuximab and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 and P-gp inhibition reduces MMAE clearance.
What to do
Monitor blood counts and for adverse reactions; consider an alternative antifungal with less CYP3A4 inhibition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Brentuximab with Itraconazole?
MediHelp rates the interaction as moderate. Brentuximab and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole is a strong CYP3A4 and P-gp inhibitor and may raise MMAE exposure from brentuximab vedotin, increasing the risk of neutropenia and other toxicities.
How serious is the interaction between Brentuximab and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for adverse reactions; consider an alternative antifungal with less CYP3A4 inhibition.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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