Drug interactions
Brentuximab + Lasmiditan
Severity: Minor
Brentuximab and Lasmiditan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro, and MMAE from brentuximab vedotin is a P-gp substrate. Exposure to MMAE may rise, but the clinical relevance is uncertain, and lasmiditan is used only intermittently for migraine.
What this interaction means in plain words
Brentuximab and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brentuximab belongs to Oncology; Lasmiditan belongs to Central Nervous System.
Why it happens
P-gp inhibition by lasmiditan may modestly raise MMAE exposure.
What to do
No routine adjustment is needed. Monitor for neutropenia and neuropathy during brentuximab treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Brentuximab with Lasmiditan?
MediHelp rates the interaction as minor. Brentuximab and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits P-glycoprotein in vitro, and MMAE from brentuximab vedotin is a P-gp substrate. Exposure to MMAE may rise, but the clinical relevance is uncertain, and lasmiditan is used only intermittently for migraine.
How serious is the interaction between Brentuximab and Lasmiditan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for neutropenia and neuropathy during brentuximab treatment.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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