Drug interactions
Brentuximab + Lonafarnib
Severity: Moderate
Brentuximab and Lonafarnib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor, and MMAE from brentuximab vedotin is a CYP3A4 substrate. Higher MMAE exposure may worsen neutropenia and neuropathy.
What this interaction means in plain words
Brentuximab and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Lonafarnib belongs to Miscellaneous.
Why it happens
CYP3A inhibition by lonafarnib reduces MMAE metabolism.
What to do
Monitor blood counts and neuropathy. Consider reducing or holding brentuximab vedotin if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Brentuximab with Lonafarnib?
MediHelp rates the interaction as moderate. Brentuximab and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a strong CYP3A inhibitor, and MMAE from brentuximab vedotin is a CYP3A4 substrate. Higher MMAE exposure may worsen neutropenia and neuropathy.
How serious is the interaction between Brentuximab and Lonafarnib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy. Consider reducing or holding brentuximab vedotin if toxicity develops.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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