Drug interactions
Brentuximab + Ribociclib
Severity: Moderate
Brentuximab and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may increase MMAE exposure from brentuximab vedotin. This could worsen myelosuppression and neuropathy, and both drugs themselves cause neutropenia.
What this interaction means in plain words
Brentuximab and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibition of CYP3A4 may reduce MMAE metabolism, with additive myelosuppression.
What to do
Monitor complete blood counts and neuropathy symptoms frequently. Delay or reduce doses according to neutropenia severity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Brentuximab with Ribociclib?
MediHelp rates the interaction as moderate. Brentuximab and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4 and may increase MMAE exposure from brentuximab vedotin. This could worsen myelosuppression and neuropathy, and both drugs themselves cause neutropenia.
How serious is the interaction between Brentuximab and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and neuropathy symptoms frequently. Delay or reduce doses according to neutropenia severity.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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