Drug interactions
Brentuximab + Selinexor
Severity: Moderate
Brentuximab and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and fatigue, and brentuximab vedotin can cause peripheral neuropathy and rarely progressive multifocal leukoencephalopathy. The adverse effects overlap and may complicate assessment, but no direct interaction mechanism is established. Both can also cause cytopenias.
What this interaction means in plain words
Brentuximab and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Selinexor belongs to Oncology.
Why it happens
No established mechanism; overlapping neurologic and hematologic toxicities.
What to do
Monitor neurologic status and blood counts. Reduce or hold selinexor if neurologic or hematologic toxicity worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Brentuximab with Selinexor?
MediHelp rates the interaction as moderate. Brentuximab and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and fatigue, and brentuximab vedotin can cause peripheral neuropathy and rarely progressive multifocal leukoencephalopathy. The adverse effects overlap and may complicate assessment, but no direct interaction mechanism is established. Both can also cause cytopenias.
How serious is the interaction between Brentuximab and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neurologic status and blood counts. Reduce or hold selinexor if neurologic or hematologic toxicity worsens.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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