Drug interactions
Brentuximab + Trastuzumab deruxtecan
Severity: Moderate
Brentuximab and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are cytotoxic antibody-drug conjugates that cause myelosuppression, so combining them may deepen neutropenia and raise infection risk. Trastuzumab deruxtecan also carries a risk of interstitial lung disease.
What this interaction means in plain words
Brentuximab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive bone marrow suppression from the cytotoxic payloads of both antibody-drug conjugates.
What to do
Monitor complete blood counts frequently and for signs of infection, and use growth factor support or dose delays according to neutropenia grade.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Brentuximab with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Brentuximab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are cytotoxic antibody-drug conjugates that cause myelosuppression, so combining them may deepen neutropenia and raise infection risk. Trastuzumab deruxtecan also carries a risk of interstitial lung disease.
How serious is the interaction between Brentuximab and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and for signs of infection, and use growth factor support or dose delays according to neutropenia grade.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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