Drug interactions
Brentuximab vedotin + Ribociclib
Severity: Moderate
Brentuximab vedotin and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cytotoxic component of brentuximab vedotin, MMAE, is metabolized by CYP3A4. Ribociclib may increase MMAE exposure and the risk of neutropenia and neuropathy.
What this interaction means in plain words
Brentuximab vedotin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab vedotin belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing MMAE clearance.
What to do
Monitor blood counts and neuropathy symptoms closely. Delay or reduce brentuximab if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Brentuximab vedotin
- Bleomycin + Brentuximab vedotin Contraindicated
- Brentuximab vedotin + Siponimod Major
- Apalutamide + Brentuximab vedotin Moderate
- Brentuximab vedotin + Clarithromycin Moderate
- Brentuximab vedotin + Imatinib Moderate
- Brentuximab vedotin + Isoniazid Moderate
Frequently asked questions
Can I take Brentuximab vedotin with Ribociclib?
MediHelp rates the interaction as moderate. Brentuximab vedotin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic component of brentuximab vedotin, MMAE, is metabolized by CYP3A4. Ribociclib may increase MMAE exposure and the risk of neutropenia and neuropathy.
How serious is the interaction between Brentuximab vedotin and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms closely. Delay or reduce brentuximab if toxicity develops.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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