Drug interactions
Brentuximab vedotin + Voriconazole
Severity: Moderate
Brentuximab vedotin and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase exposure to the cytotoxic payload MMAE released from brentuximab vedotin. This may increase the risk or severity of neutropenia and peripheral neuropathy.
What this interaction means in plain words
Brentuximab vedotin and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab vedotin belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, which metabolizes MMAE.
What to do
Monitor blood counts and neuropathy symptoms, and hold or modify brentuximab dosing per labeling if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Brentuximab vedotin
- Bleomycin + Brentuximab vedotin Contraindicated
- Brentuximab vedotin + Siponimod Major
- Apalutamide + Brentuximab vedotin Moderate
- Brentuximab vedotin + Clarithromycin Moderate
- Brentuximab vedotin + Imatinib Moderate
- Brentuximab vedotin + Isoniazid Moderate
Frequently asked questions
Can I take Brentuximab vedotin with Voriconazole?
MediHelp rates the interaction as moderate. Brentuximab vedotin and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may increase exposure to the cytotoxic payload MMAE released from brentuximab vedotin. This may increase the risk or severity of neutropenia and peripheral neuropathy.
How serious is the interaction between Brentuximab vedotin and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms, and hold or modify brentuximab dosing per labeling if toxicity develops.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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