Drug interactions
Brexanolone + Metoclopramide
Severity: Moderate
Brexanolone and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes dose-related sedation and loss of consciousness, and metoclopramide can add to drowsiness. Combined use may increase CNS depression.
What this interaction means in plain words
Brexanolone and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects (GABA-A modulation with metoclopramide sedation).
What to do
Monitor continuously for excessive sedation during the infusion, and reduce or interrupt brexanolone if sedation occurs. Avoid unnecessary metoclopramide use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Brexanolone with Metoclopramide?
MediHelp rates the interaction as moderate. Brexanolone and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone causes dose-related sedation and loss of consciousness, and metoclopramide can add to drowsiness. Combined use may increase CNS depression.
How serious is the interaction between Brexanolone and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor continuously for excessive sedation during the infusion, and reduce or interrupt brexanolone if sedation occurs. Avoid unnecessary metoclopramide use.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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