Drug interactions
Brexpiprazole + Brompheniramine
Severity: Moderate
Brexpiprazole and Brompheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine, and brexpiprazole also causes somnolence. Combined use can deepen drowsiness and impair alertness and psychomotor performance.
What this interaction means in plain words
Brexpiprazole and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Brompheniramine belongs to Respiratory.
Why it happens
Additive CNS depression from H1 antagonism and antipsychotic sedative effects.
What to do
Warn the patient about increased drowsiness and avoid driving if affected. Use a non-sedating antihistamine where an antihistamine is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brexpiprazole and Brompheniramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Brexpiprazole
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brexpiprazole with Brompheniramine?
MediHelp rates the interaction as moderate. Brexpiprazole and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine, and brexpiprazole also causes somnolence. Combined use can deepen drowsiness and impair alertness and psychomotor performance.
How serious is the interaction between Brexpiprazole and Brompheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about increased drowsiness and avoid driving if affected. Use a non-sedating antihistamine where an antihistamine is needed.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
