Drug interactions
Brexpiprazole + Carbinoxamine
Severity: Minor
Brexpiprazole and Carbinoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine with anticholinergic effects, so it may add to the somnolence of brexpiprazole. Impaired alertness and falls are the main concerns, particularly in older patients.
What this interaction means in plain words
Brexpiprazole and Carbinoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brexpiprazole belongs to Central Nervous System; Carbinoxamine belongs to Respiratory.
Why it happens
Additive CNS depression from H1 receptor antagonism and the sedative effect of brexpiprazole.
What to do
Advise caution with driving and alcohol, and consider a non-sedating antihistamine if drowsiness is a problem.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brexpiprazole
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Brexpiprazole with Carbinoxamine?
MediHelp rates the interaction as minor. Brexpiprazole and Carbinoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbinoxamine is a sedating first-generation antihistamine with anticholinergic effects, so it may add to the somnolence of brexpiprazole. Impaired alertness and falls are the main concerns, particularly in older patients.
How serious is the interaction between Brexpiprazole and Carbinoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise caution with driving and alcohol, and consider a non-sedating antihistamine if drowsiness is a problem.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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