Drug interactions
Brexpiprazole + Chloramphenicol
Severity: Moderate
Brexpiprazole and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may increase brexpiprazole exposure through CYP3A4 inhibition, raising the risk of sedation, akathisia and orthostatic hypotension. The effect is likely less than with strong inhibitors.
What this interaction means in plain words
Brexpiprazole and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Chloramphenicol inhibits CYP3A4, which partly metabolizes brexpiprazole.
What to do
Monitor for increased adverse effects and reduce the brexpiprazole dose if they occur. Reassess the dose when chloramphenicol is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brexpiprazole and Chloramphenicol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chloramphenicol
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Chloramphenicol?
MediHelp rates the interaction as moderate. Brexpiprazole and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may increase brexpiprazole exposure through CYP3A4 inhibition, raising the risk of sedation, akathisia and orthostatic hypotension. The effect is likely less than with strong inhibitors.
How serious is the interaction between Brexpiprazole and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased adverse effects and reduce the brexpiprazole dose if they occur. Reassess the dose when chloramphenicol is stopped.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
