Drug interactions
Brexpiprazole + Chlorpheniramine
Severity: Moderate
Brexpiprazole and Chlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a sedating antihistamine and brexpiprazole can also cause somnolence. Together they may produce greater drowsiness and impaired concentration.
What this interaction means in plain words
Brexpiprazole and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Chlorpheniramine belongs to Respiratory.
Why it happens
Additive CNS depression via H1 antagonism and antipsychotic sedation.
What to do
Advise the patient about added drowsiness and avoidance of driving if impaired. Prefer a non-sedating antihistamine when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Brexpiprazole with Chlorpheniramine?
MediHelp rates the interaction as moderate. Brexpiprazole and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a sedating antihistamine and brexpiprazole can also cause somnolence. Together they may produce greater drowsiness and impaired concentration.
How serious is the interaction between Brexpiprazole and Chlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient about added drowsiness and avoidance of driving if impaired. Prefer a non-sedating antihistamine when feasible.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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