Drug interactions
Brexpiprazole + Chlorzoxazone
Severity: Moderate
Brexpiprazole and Chlorzoxazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole can cause somnolence, and chlorzoxazone adds its own sedative effect. The combination may increase drowsiness and impair coordination.
What this interaction means in plain words
Brexpiprazole and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Chlorzoxazone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation and dizziness, and advise caution when driving. Reduce the dose of chlorzoxazone if sedation is problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Chlorzoxazone?
MediHelp rates the interaction as moderate. Brexpiprazole and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexpiprazole can cause somnolence, and chlorzoxazone adds its own sedative effect. The combination may increase drowsiness and impair coordination.
How serious is the interaction between Brexpiprazole and Chlorzoxazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and dizziness, and advise caution when driving. Reduce the dose of chlorzoxazone if sedation is problematic.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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