Drug interactions
Brexpiprazole + Dapagliflozin-metformin
Severity: Minor
Brexpiprazole and Dapagliflozin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole may be associated with hyperglycemia and weight gain, which could weaken glycemic control in patients treated with dapagliflozin-metformin. The effect is usually modest.
What this interaction means in plain words
Brexpiprazole and Dapagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brexpiprazole belongs to Central Nervous System; Dapagliflozin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism via antipsychotic-related metabolic effects on insulin sensitivity.
What to do
Monitor glucose and HbA1c periodically after starting brexpiprazole and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Dapagliflozin-metformin?
MediHelp rates the interaction as minor. Brexpiprazole and Dapagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brexpiprazole may be associated with hyperglycemia and weight gain, which could weaken glycemic control in patients treated with dapagliflozin-metformin. The effect is usually modest.
How serious is the interaction between Brexpiprazole and Dapagliflozin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c periodically after starting brexpiprazole and adjust antidiabetic therapy if needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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