Drug interactions
Brexpiprazole + Desipramine
Severity: Moderate
Brexpiprazole and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole is cleared via CYP2D6 and CYP3A4, and desipramine is a weak to moderate CYP2D6 inhibitor that may raise brexpiprazole exposure. Exposure rises more if a CYP3A4 inhibitor is also given. Additive sedation and orthostatic effects can also occur.
What this interaction means in plain words
Brexpiprazole and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Desipramine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated brexpiprazole metabolism plus additive CNS depressant effects.
What to do
Monitor for brexpiprazole adverse effects such as akathisia, sedation and orthostasis, and reduce its dose if needed; follow labeling for dose reduction when combined with both CYP2D6 and CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Desipramine?
MediHelp rates the interaction as moderate. Brexpiprazole and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexpiprazole is cleared via CYP2D6 and CYP3A4, and desipramine is a weak to moderate CYP2D6 inhibitor that may raise brexpiprazole exposure. Exposure rises more if a CYP3A4 inhibitor is also given. Additive sedation and orthostatic effects can also occur.
How serious is the interaction between Brexpiprazole and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for brexpiprazole adverse effects such as akathisia, sedation and orthostasis, and reduce its dose if needed; follow labeling for dose reduction when combined with both CYP2D6 and CYP3A4 inhibitors.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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