Drug interactions
Brexpiprazole + Deutetrabenazine
Severity: Moderate
Brexpiprazole and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, and deutetrabenazine can also cause depression, akathisia and parkinsonism, which may be worsened by dopamine blockade from brexpiprazole. Combined use may increase sedation and movement-related adverse effects.
What this interaction means in plain words
Brexpiprazole and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and dopaminergic antagonism or depletion via D2 blockade plus VMAT2 inhibition.
What to do
Monitor for sedation, akathisia, parkinsonism and mood changes, and adjust doses as needed. Counsel on driving and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Brexpiprazole with Deutetrabenazine?
MediHelp rates the interaction as moderate. Brexpiprazole and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence, and deutetrabenazine can also cause depression, akathisia and parkinsonism, which may be worsened by dopamine blockade from brexpiprazole. Combined use may increase sedation and movement-related adverse effects.
How serious is the interaction between Brexpiprazole and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, akathisia, parkinsonism and mood changes, and adjust doses as needed. Counsel on driving and avoid alcohol.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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