Drug interactions
Brexpiprazole + Doxepin
Severity: Moderate
Brexpiprazole and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is strongly sedating through H1 blockade, and brexpiprazole adds further sedation and possible orthostatic hypotension. Doxepin is also a CYP2D6 substrate and a weak inhibitor, though a clinically important effect on brexpiprazole levels is not established.
What this interaction means in plain words
Brexpiprazole and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Doxepin belongs to Dermatology.
Why it happens
Additive CNS depression and hypotensive effects via histamine and alpha-adrenergic blockade.
What to do
Monitor for sedation, orthostatic hypotension and anticholinergic effects, and start with low doses. Adjust either dose if daytime impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Brexpiprazole with Doxepin?
MediHelp rates the interaction as moderate. Brexpiprazole and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is strongly sedating through H1 blockade, and brexpiprazole adds further sedation and possible orthostatic hypotension. Doxepin is also a CYP2D6 substrate and a weak inhibitor, though a clinically important effect on brexpiprazole levels is not established.
How serious is the interaction between Brexpiprazole and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and anticholinergic effects, and start with low doses. Adjust either dose if daytime impairment occurs.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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