Drug interactions
Brexpiprazole + Duvelisib
Severity: Moderate
Brexpiprazole and Duvelisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is a CYP3A4 inhibitor and may raise brexpiprazole exposure. Adverse effects such as sedation, akathisia and orthostatic hypotension may increase.
What this interaction means in plain words
Brexpiprazole and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Duvelisib belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4, reducing brexpiprazole clearance.
What to do
Monitor for brexpiprazole adverse effects and reduce the dose if they occur. Use a quarter dose if a CYP2D6 inhibitor is also present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Brexpiprazole with Duvelisib?
MediHelp rates the interaction as moderate. Brexpiprazole and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib is a CYP3A4 inhibitor and may raise brexpiprazole exposure. Adverse effects such as sedation, akathisia and orthostatic hypotension may increase.
How serious is the interaction between Brexpiprazole and Duvelisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for brexpiprazole adverse effects and reduce the dose if they occur. Use a quarter dose if a CYP2D6 inhibitor is also present.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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