Drug interactions
Brexpiprazole + Eszopiclone
Severity: Moderate
Brexpiprazole and Eszopiclone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole can cause somnolence and orthostatic effects, and eszopiclone adds sedative-hypnotic effects. Combined use may increase drowsiness and impair alertness and coordination.
What this interaction means in plain words
Brexpiprazole and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Eszopiclone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective eszopiclone dose and monitor for oversedation and falls. Counsel patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Eszopiclone?
MediHelp rates the interaction as moderate. Brexpiprazole and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexpiprazole can cause somnolence and orthostatic effects, and eszopiclone adds sedative-hypnotic effects. Combined use may increase drowsiness and impair alertness and coordination.
How serious is the interaction between Brexpiprazole and Eszopiclone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective eszopiclone dose and monitor for oversedation and falls. Counsel patients to avoid driving until the response is known.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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