Drug interactions
Brexpiprazole + Imatinib
Severity: Moderate
Brexpiprazole and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 and CYP2D6, both of which clear brexpiprazole, so exposure may rise. This may increase sedation, akathisia, and orthostatic hypotension.
What this interaction means in plain words
Brexpiprazole and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4 and CYP2D6, reducing brexpiprazole clearance.
What to do
Monitor for adverse effects and consider a brexpiprazole dose reduction. Use labeled reductions if other CYP2D6 or CYP3A4 inhibitors are also taken.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Brexpiprazole with Imatinib?
MediHelp rates the interaction as moderate. Brexpiprazole and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP3A4 and CYP2D6, both of which clear brexpiprazole, so exposure may rise. This may increase sedation, akathisia, and orthostatic hypotension.
How serious is the interaction between Brexpiprazole and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and consider a brexpiprazole dose reduction. Use labeled reductions if other CYP2D6 or CYP3A4 inhibitors are also taken.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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