Drug interactions
Brexpiprazole + Lapatinib
Severity: Moderate
Brexpiprazole and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib weakly to moderately inhibits CYP3A4 and may increase brexpiprazole exposure. The effect matters mainly when combined with CYP2D6 inhibition or in poor metabolizers.
What this interaction means in plain words
Brexpiprazole and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Lapatinib belongs to Oncology.
Why it happens
Lapatinib inhibits CYP3A4, decreasing brexpiprazole metabolism.
What to do
Monitor for sedation, akathisia, and hypotension. Reduce brexpiprazole to a quarter of the usual dose if a CYP2D6 inhibitor is also used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Brexpiprazole with Lapatinib?
MediHelp rates the interaction as moderate. Brexpiprazole and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib weakly to moderately inhibits CYP3A4 and may increase brexpiprazole exposure. The effect matters mainly when combined with CYP2D6 inhibition or in poor metabolizers.
How serious is the interaction between Brexpiprazole and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, akathisia, and hypotension. Reduce brexpiprazole to a quarter of the usual dose if a CYP2D6 inhibitor is also used.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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