Drug interactions
Brexpiprazole + Lemborexant
Severity: Moderate
Brexpiprazole and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is a sedative-hypnotic orexin antagonist and brexpiprazole also causes somnolence. Combining them may increase sedation, next-day impairment and falls risk.
What this interaction means in plain words
Brexpiprazole and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Lemborexant belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Use the lowest effective lemborexant dose and counsel about next-day drowsiness and driving. Monitor for excessive sedation and falls, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Lemborexant
Frequently asked questions
Can I take Brexpiprazole with Lemborexant?
MediHelp rates the interaction as moderate. Brexpiprazole and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lemborexant is a sedative-hypnotic orexin antagonist and brexpiprazole also causes somnolence. Combining them may increase sedation, next-day impairment and falls risk.
How serious is the interaction between Brexpiprazole and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lemborexant dose and counsel about next-day drowsiness and driving. Monitor for excessive sedation and falls, especially in older patients.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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