Drug interactions
Brexpiprazole + Lenacapavir
Severity: Moderate
Brexpiprazole and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor, and its effect can persist for months after subcutaneous dosing. Brexpiprazole exposure may rise, increasing dose-related adverse effects.
What this interaction means in plain words
Brexpiprazole and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Lenacapavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by lenacapavir reduces brexpiprazole metabolism.
What to do
Monitor for sedation, akathisia and orthostasis, and consider reducing the brexpiprazole dose, particularly if the patient is also a CYP2D6 poor metabolizer or on a CYP2D6 inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Brexpiprazole with Lenacapavir?
MediHelp rates the interaction as moderate. Brexpiprazole and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A4 inhibitor, and its effect can persist for months after subcutaneous dosing. Brexpiprazole exposure may rise, increasing dose-related adverse effects.
How serious is the interaction between Brexpiprazole and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, akathisia and orthostasis, and consider reducing the brexpiprazole dose, particularly if the patient is also a CYP2D6 poor metabolizer or on a CYP2D6 inhibitor.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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