Drug interactions
Brexpiprazole + Levetiracetam
Severity: Moderate
Brexpiprazole and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, fatigue and dizziness. Combined use may increase sedation and impair alertness.
What this interaction means in plain words
Brexpiprazole and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Monitor for sedation and mood or behavioral changes, as levetiracetam can cause irritability. Advise caution with driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Levetiracetam
Frequently asked questions
Can I take Brexpiprazole with Levetiracetam?
MediHelp rates the interaction as moderate. Brexpiprazole and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence, fatigue and dizziness. Combined use may increase sedation and impair alertness.
How serious is the interaction between Brexpiprazole and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and mood or behavioral changes, as levetiracetam can cause irritability. Advise caution with driving until tolerance is established.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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