Drug interactions
Brexpiprazole + Metaxalone
Severity: Moderate
Brexpiprazole and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, so combined use may deepen sedation and impair judgment and motor skills.
What this interaction means in plain words
Brexpiprazole and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excessive sedation and dizziness. Counsel patients to avoid driving or hazardous tasks until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Metaxalone?
MediHelp rates the interaction as moderate. Brexpiprazole and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, so combined use may deepen sedation and impair judgment and motor skills.
How serious is the interaction between Brexpiprazole and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and dizziness. Counsel patients to avoid driving or hazardous tasks until tolerance is established.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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