Drug interactions
Brexpiprazole + Methohexital
Severity: Moderate
Brexpiprazole and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic, and brexpiprazole has sedating properties, so the combination can deepen sedation and prolong recovery. Hypotension and respiratory depression may also be more pronounced during anesthesia.
What this interaction means in plain words
Brexpiprazole and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive central nervous system depression from the barbiturate anesthetic and the antipsychotic.
What to do
Inform the anesthesia team about brexpiprazole therapy and titrate methohexital to effect. Monitor blood pressure, oxygenation and recovery time closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Methohexital
Frequently asked questions
Can I take Brexpiprazole with Methohexital?
MediHelp rates the interaction as moderate. Brexpiprazole and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anesthetic, and brexpiprazole has sedating properties, so the combination can deepen sedation and prolong recovery. Hypotension and respiratory depression may also be more pronounced during anesthesia.
How serious is the interaction between Brexpiprazole and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team about brexpiprazole therapy and titrate methohexital to effect. Monitor blood pressure, oxygenation and recovery time closely.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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