Drug interactions
Brexpiprazole + Mifepristone
Severity: Moderate
Brexpiprazole and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4, and brexpiprazole is partly cleared by CYP3A4, so exposure to brexpiprazole may increase. This could heighten sedation, akathisia and other dose-related adverse effects.
What this interaction means in plain words
Brexpiprazole and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by mifepristone reduces brexpiprazole clearance.
What to do
Monitor for adverse effects and consider reducing the brexpiprazole dose, following labeling for strong CYP3A4 inhibitors. Reduce further if a CYP2D6 inhibitor is also given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Brexpiprazole with Mifepristone?
MediHelp rates the interaction as moderate. Brexpiprazole and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4, and brexpiprazole is partly cleared by CYP3A4, so exposure to brexpiprazole may increase. This could heighten sedation, akathisia and other dose-related adverse effects.
How serious is the interaction between Brexpiprazole and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and consider reducing the brexpiprazole dose, following labeling for strong CYP3A4 inhibitors. Reduce further if a CYP2D6 inhibitor is also given.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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