Drug interactions
Brexpiprazole + Nalbuphine
Severity: Moderate
Brexpiprazole and Nalbuphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole can cause somnolence and orthostatic changes, and these may be added to the sedation produced by nalbuphine. Psychomotor performance may be impaired, particularly at the start of treatment.
What this interaction means in plain words
Brexpiprazole and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Nalbuphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid activity and antipsychotic receptor blockade.
What to do
Monitor for sedation and dizziness when the combination is started or doses are raised. Advise the patient to avoid driving until the effect is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brexpiprazole and Nalbuphine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Nalbuphine?
MediHelp rates the interaction as moderate. Brexpiprazole and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexpiprazole can cause somnolence and orthostatic changes, and these may be added to the sedation produced by nalbuphine. Psychomotor performance may be impaired, particularly at the start of treatment.
How serious is the interaction between Brexpiprazole and Nalbuphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and dizziness when the combination is started or doses are raised. Advise the patient to avoid driving until the effect is known.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
