Drug interactions
Brexpiprazole + Nicardipine
Severity: Minor
Brexpiprazole and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a weak to moderate CYP3A4 inhibitor and may modestly raise brexpiprazole exposure. The labeled dose reductions apply to strong inhibitors, so nicardipine alone is unlikely to require adjustment. Increased sedation, akathisia, or orthostatic hypotension are possible.
What this interaction means in plain words
Brexpiprazole and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brexpiprazole belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Weak to moderate CYP3A4 inhibition by nicardipine reduces brexpiprazole clearance.
What to do
No empirical dose change is needed. Monitor for sedation, akathisia and hypotension, and reduce the dose if a strong CYP2D6 or CYP3A4 inhibitor is also present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Nicardipine?
MediHelp rates the interaction as minor. Brexpiprazole and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine is a weak to moderate CYP3A4 inhibitor and may modestly raise brexpiprazole exposure. The labeled dose reductions apply to strong inhibitors, so nicardipine alone is unlikely to require adjustment. Increased sedation, akathisia, or orthostatic hypotension are possible.
How serious is the interaction between Brexpiprazole and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for sedation, akathisia and hypotension, and reduce the dose if a strong CYP2D6 or CYP3A4 inhibitor is also present.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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